Drug determination can be carried out in biological samples (e.g. blood, plasma, urine or tissue) as well as in samples taken from in vitro trials (filters, solutions, test vials, etc.). Drug extraction is performed by solid phase extraction (pipetting robot) or liquid/liquid extraction.
Please find here an overview of our test systems.
The method validation for the determination of drugs in biological samples is performed according to standards set by authorities.
The validation can be performed for all of our systems in use. Furthermore, methods for the determination of purity and drug content
can also be validated.
Standards set by authorities:
One of the factors important in the development of new drugs is the stability of the substances in biological matrices. We offer not only the investigation regarding the influence of pH and temperature on drug behaviour but also stability investigations in blood, plasma, urine, liver, homogenates and intestine and in certain defined enzyme solutions.
We perform quick and reliable tests to quantify drugs and their metabolites in biological samples (e.g. blood, plasma, urine or tissue). We also offer the determination of hormones or mediators.
We offer not only unspecific investigations of metabolites using intestine or liver homogenates, liver cells or microsomes, but also specific tests using enzymes of your choice. The mol masses of the generated metabolites can be determined in a further study and thus be used to clarify their structure.
In order to further characterize drugs, test trials can be performed to determine protein binding, coefficient of variation and the maximum solubility.
Complementary studies can be performed to quantify drugs in test items and to determine their purity. Impurity profiles are generated
and molecular masses of impurties can be determined.
